Molecular Evidences for the Biosynthesis of Pederin by Endosymbiont

Pederin belongs to a group of antitumor compounds found in terrestrial beetles and marine sponges. It is apparently used by some members of the rove beetle Paederus as a chemical defense against predators. A recent cluster analysis of the putative pederin biosynthesis gene (ped) strongly suggests that pederin is produced by bacterial symbionts. This paper reviewed the criteria for proving symbiontic origin of bioactive metabolite, indirect and molecular evidences for pederin bacterial origin, as well as three sets ofped clusters and putative biosynthesis process of pederin.

作 者： LIU Zhi-ping WU Xuan WANG Jin-jun HUANG Fang   作者單位： LIU Zhi-ping,WANG Jin-jun(Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing 400716,P. R, China)

WU Xuan(Chongqing Animal Disease Control Center, Chongqing 401147, P.R. China)

HUANG Fang(College of Medicine, Shanxi Datong University, Datong 037008, P.R.China) 

刊 名： 中國農業(yè)科學（英文版）  英文刊名： AGRICULTURAL SCIENCES IN CHINA  年，卷(期)： 2009 8(11)  分類號： S1  關鍵詞： pederin   PKS/NRPS   endosymbiout  

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